计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
ACY-1083
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
充氩,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC 50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy
In Vitro
Treatment with ACY-1083 (30 and 300 nM) significantly improves cell viability in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mouse hippocampal (HT22) cells Concentration: 30 and 300 nM Incubation Time: Result: Significant improvement in cell viability.
In Vivo
ACY-1083 (i.p.; 10 mg/kg; for 7 days) effectively relieves Cisplatin-induced mechanical allodynia in C57BL/6J mice ACY-1083 (oral doses of 3 mg/kg ACY-1083 for 7 days) reverses Paclitaxel-induced mechanical allodynia in adult male SD rats. Mice dosed with 5 mg/kg ACY-1083 by intraperitoneal (i.p.) injection have a maximum plasma concentration (C max ) of 936 ng/mL, a half-life (T 1/2 ) of 3.5 hours, and a biologically active plasma exposure of 8 hours after dosing. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult male C57BL/6J mice of 8-10 weeks of age Dosage: 3 or 10 mg/kg Administration: Administered i.p. injection; daily; for 7 days Result: The 10 mg/kg relieved Cisplatin (2.3 mg/kg)-induced mechanical allodynia, whereas the 3 mg/kg dose did not. Animal Model: Adult male Sprague Dawley rats Dosage: 3 mg/kg Administration: Two daily doses were given orally for 7 days. Result: Reversed Paclitaxel (6 mg/kg or 12 mg/kg)-induced mechanical allodynia.
IC50& Target:HDAC6 3 nM (IC 50 )
规格
规格或纯度
Moligand™,10mM in DMSO
英文名称
ACY-1083
生化机理
ACY-1083 是一种选择性穿脑 HDAC6 抑制剂，其 IC 50 为 3 nM，对 HDAC6 的选择性是所有其他 HDAC 同工酶的 260 倍。ACY-1083 能有效逆转化疗引起的周围神经病变。
储存条件
充氩,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
C1CC(CCC1(C2=CC=CC=C2)NC3=NC=C(C=N3)C(=O)NO)(F)F
PubChem CID
分子量
348.35
技术文档
高级数据
关联靶点（人）
HDAC6
Tclin
组蛋白去乙酰化酶6(Histone deacetylase 6)
(3 活性数据)
HDAC1
Tclin
组蛋白去乙酰化酶1(Histone deacetylase 1)
(3 活性数据)
HDAC2
Tclin
组蛋白去乙酰化酶2(Histone deacetylase 2)
(1 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）