计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
概述
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities.
In Vitro
ASP2905 potently inhibits potassium currents in CHO cells expressing KCNH3 (IC 50 of 9.0 nM). ASP2905 (≤10 μM) minimally bound with low affinities to 55 transmembrane proteins. ASP2905 (0.1 µM, 1 µM) decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ASP2905 treatment inhibits hyperlocomotion induced by Phencyclidine. And significantly ameliorates Phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ddY mice (aged 4-5 weeks) injected with Phencyclidine hydrochloride (PCP)Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg Administration: Oral administration; once Result: Inhibited hyperlocomotion induced by Phencyclidine.
规格
规格或纯度
10mM in DMSO
英文名称
ASP2905
生化机理
ASP2905 是一种由 Kcnh3/BEC1 基因编码的强效选择性钾通道 Kv12.2 抑制剂。ASP2905 可穿过血脑屏障，具有抗精神病活性。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
C1=CC=C(C=C1)NC2=NC(=NC(=N2)NCC3=NC=CC=N3)NC4=CC=C(C=C4)F
PubChem CID
MeSH Entry Terms
ASP2905;N-(4-fluorophenyl)-N'-phenyl-N'-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine
分子量
388.40
高级数据
关联靶点（人）
KCNH3
Tclin
钾电压门控通道亚家族H成员3(Potassium voltage-gated channel subfamily H member 3)
(2 活性数据)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 J2610917 |
分析证书 | A655589 |
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 SSE:688179 保留所有权利。
危险品化学品经营许可证（带存储）