计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC 50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently
In Vitro
ATX inhibitor 5 (compound 10g) (IC 50 s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC). ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: CFs and t-HSC/Cl-6 cells Concentration: 0.0001, 0.01, 1, 100, 10000 µM Incubation Time: 48 hours Result: Displayed activities against CFs and t-HSC/Cl-6 cells with IC 50 s of 1.21 and 0.78 µM, respectively.
In Vivo
ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Konmin mice (8-week old, 22-25 g) Dosage: 20, 40 mg/kg Administration: Orally; once daily for two weeks Result: Prominently reduced CCl4-induced hepatic fibrosis level.
IC50& Target:Autotaxin
规格
别名
ATX 抑制剂 5
规格或纯度
10mM in DMSO
英文名称
ATX inhibitor 5
生化机理
ATX 抑制剂 5 是一种强效的口服活性自体交联素（ATX）抑制剂，其 IC 50 为 15.3 nM。ATX 抑制剂 5 具有抗肝纤维化的作用，能显著降低 CCl4 诱导的肝纤维化水平。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
C1CN(CC2=C1N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)C(=O)N/N=C/C4=CC=C(C=C4)Cl
PubChem CID
分子量
474.87
技术文档
高级数据
关联靶点（人）
ENPP2
Tchem
外核苷酸焦磷酸酶/磷酸二酯酶家族成员 2(Ectonucleotide pyrophosphatase/phosphodiesterase family member 2)
(1 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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