计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
概述
Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein) , with an IC 50 of 2 nM. Atuliflapon is used in the study for coronary artery disease
In Vitro
Atuliflapon demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Atuliflapon exhibits an IC 50 of 39 nM for LTB 4. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively . Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 2 nM (FLAP)
规格
别名
阿图利弗
规格或纯度
10mM in DMSO
英文名称
Atuliflapon
生化机理
Atuliflapon（AZD5718）是一种口服活性的 5-脂氧合酶激活蛋白（FLAP）抑制剂，其 IC 50 为 2 nM。Atuliflapon 用于冠状动脉疾病的研究。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
CC1=CC(=NN1)C2=CC=C(C=C2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4=C5C(=O)NCCN5N=C4
关联CAS
PubChem CID
MeSH Entry Terms
AZD5718
分子量
446.50
高级数据
关联靶点（人）
ALOX5AP
Tchem
花生四烯酸5-脂氧合酶活化蛋白(Arachidonate 5-lipoxygenase-activating protein)
(0 活性数据)
安全和危险性（GHS）
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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危险品化学品经营许可证（带存储）