计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
BRCC45/BRE Antibody
有货
为什么选择此级别
无载体 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Rabbit anti Human BRCC45/BRE Antibody, Polyclonal antibody, could be used for WB, IHC and so on.
规格
产品名称
BRCC45/BRE Antibody
别名
BRCC45/BRE抗体 | BRCC45/BRE多克隆抗体 | BRCC45/BRE兔多抗
英文别名
6030405P19Rik antibody | AI429776 antibody | B830038C02Rik antibody | Brain and reproductive organ expressed (TNFRSF1A modulator) antibody | brain and reproductive organ expressed protein antibody | Brain and reproductive organ-expressed protein antibody
规格或纯度
无载体, 见COA
生化机理
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
宿主种属
兔(Rabbit)
特异性
BABAM2
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human BABAM2 (AA 1-382).
阳性对照
WB: Human normal colon lysates. IHC: Human liver cancer tissue
偶联
Unconjugated
克隆类型
多克隆抗体
Format
Whole IgG
纯化方法
Antigen affinity purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, 40% Glycerol, 0.05% Sodium azide, pH 7.4.
防腐剂
0.05% Sodium azide
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。
应用
应用名称
稀释比例
WB
1/500-1/2000
IHC
1/50-1/200
技术文档
高级数据
关联靶点（人）
BABAM2
Tbio
BRISC 和 BRCA1-A 复合物成员 2(BRISC and BRCA1-A complex member 2)
(0 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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