Rabbit anti Human CAMKIV Antibody, Recombinant, could be used for WB and so on.
规格
产品名称
Recombinant CAMKIV Antibody
别名
CAMKIV抗体 | CAMKIV重组抗体 | 钙/钙调蛋白依赖性蛋白激酶4抗体
英文别名
Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody | Brain Ca(2+) calmodulin dependent protein kinase type IV antibody | Brain Ca++-calmodulin dependent protein kinase type IV antibody | Calcium / calmodulin dependent protein kinase type 4 c
规格或纯度
ExactAb™, 重组, 已验证, 见COA
生化机理
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
宿主种属
兔(Rabbit)
特异性
CAMKIV
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human CAMKIV (AA 420-473).
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant CAMKIV Antibody (Ab092670) - Western Blot All lanes: Recombinant CAMKIV Antibody (Ab092670) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/40000 dilution
Predicted band size: 52 kDa Observed band size: 57 kDa Exposure time: 84.8 s
Recombinant CAMKIV Antibody (Ab092670) - Western Blot All lanes: Recombinant CAMKIV Antibody (Ab092670) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/40000 dilution
Predicted band size: 52 kDa Observed band size: 57 kDa Exposure time: 84.8 s
ZJ25F0218703
危险品化学品经营许可证（带存储）