Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Post-translational: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
宿主种属
兔(Rabbit)
特异性
Caspase-1
种属反应性
人(Human),大鼠(Rat)
免疫原
A synthetic peptide derived from human Caspase 1 (AA 250-404).
Recombinant Caspase-1 Antibody (Ab092974) - Western Blot All lanes: Recombinant Caspase-1 Antibody (Ab092974) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution
Predicted band size: 45 kDa Observed band size: 42 kDa Exposure time: 80.0 s
Recombinant Caspase-1 Antibody (Ab092974) - IHC Immunohistochemical analysis of paraffin-embedded human liver, using Recombinant Caspase-1 Antibody (Ab092974).