计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
Cullin 4B/CUL-4B Mouse mAb
有货
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Mouse anti Human Cullin 4B/CUL-4B Antibody, Monoclonal (OTI1C4), could be used for WB, IHC and so on.
规格
产品名称
Cullin 4B/CUL-4B Mouse mAb
别名
CUL-4B抗体 | CUL4B蛋白抗体
英文别名
CUL 4Bantibody | CUL-4B antibody | CUL4B antibody | CUL4B_HUMAN antibody | Cullin-4B antibody | DKFZp686F1470 antibody | KIAA0695 antibody | MRXHF2 antibody | MRXSC antibody | SFM2 antibody | SFM2 | MRXSC | CUL-4B | MRXHF2 | MRXS15
规格或纯度
见COA
生化机理
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
Post-translational: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
宿主种属
小鼠(Mouse)
特异性
CUL4B
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog)
免疫原
Recombinant protein of human CUL4B (AA 1-300).
阳性对照
WB: HepG2, HeLa, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates. IHC: Human pancreas, thyroid, prostate tissues.
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
纯化方法
Protein A/G purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3
防腐剂
0.02% Sodium azide
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。
应用
应用名称
稀释比例
WB
1/2000
IHC
1/100
技术文档
高级数据
关联靶点（人）
CUL4B
Tbio
库林-4B(Cullin-4B)
(0 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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