Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). Isoform 2: Does not associate with membranes but has a diacylglycerol kinase activity.
宿主种属
小鼠(Mouse)
特异性
DGKB
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),狗(Dog),猴(Monkey)
免疫原
Recombinant full length protein of human DGKB produced in HEK293T cell.
阳性对照
WB: HEK293T transfected with pCMV6-ENTRY DGKB cDNA for 48 hrs; HepG2, HeLa, HT29, A549, COS7, Jurkat, MDCK, PC12, MCF7 lysates.