Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death.
宿主种属
兔(Rabbit)
特异性
GPR39
种属反应性
人(Human),小鼠(Mouse)
免疫原
A synthetic peptide derived from human GPR39.
阳性对照
WB: Mouse kidney lysates. IHC: Human liver cancer tissues.