Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
Post-translational: Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
宿主种属
兔(Rabbit)
特异性
IL-1 beta/IL1B
种属反应性
人(Human),小鼠(Mouse)
免疫原
Recombinant protein of human IL1B.
阳性对照
WB: PC3, Mouse skeletal muscle, NIH/3T3 lysates. IHC: Human lung cancer, colorectal cancer tissues.