Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor.
Post-translational: Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.
Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.
宿主种属
兔(Rabbit)
特异性
IRF1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human IRF1 (AA 110-325).
阳性对照
WB: MOLT-4, Raji, K562 and MCF7 cell lysates. IHC: Rat kidney tissue. IF/ICC: HeLa cells.
Recombinant IRF1 Antibody (Ab111193) - Western Blot All lanes: Recombinant IRF1 Antibody (Ab111193) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution
Predicted band size: 37 kDa Observed band size: 49 kDa Exposure time: 80.0 s
Recombinant IRF1 Antibody (Ab111193) - IHC Immunohistochemical analysis of paraffin-embedded rat kidney, using Recombinant IRF1 Antibody (Ab111193).
Recombinant IRF1 Antibody (Ab111193) - IF/ICC Immunofluorescent analysis of Hela cells, using Recombinant IRF1 Antibody (Ab111193).
ZJ25F0724977
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