Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
宿主种属
小鼠(Mouse)
特异性
Livin/BIRC7
种属反应性
人(Human),小鼠(Mouse)
免疫原
Recombinant protein of human BIRC7 (AA 1-280).
阳性对照
WB: Mouse liver, Human liver lysates. IHC: Human liver cancer tissue. Flow Cytometry: Jurkat, HeLa cells.