Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.
Post-translational: Phosphorylated and activated by MAP kinase.
宿主种属
兔(Rabbit)
特异性
MK2
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human MK2 (AA 350-400).
Recombinant MK2 Antibody (Ab115489) - Western Blot All lanes: Recombinant MK2 Antibody (Ab115489) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 46 kDa Observed band size: 47, 56 kDa Exposure time: 45.4 s MAPKAPK2 (MK2) is a key kinase downstream of the p38 MAPK signaling pathway. Two isoforms generated by alternative splicing exist, with molecular weights ranging approximately from 42 - 60 kDa (PMID: 10666409; 11328854; 8995385).
Recombinant MK2 Antibody (Ab115489) - Western Blot All lanes use Recombinant MK2 Antibody (Ab115489) at 1/1000 dilution for 1 hour at room temperature.
ZJ25F0825485
危险品化学品经营许可证（带存储）