Rabbit anti Human MTF2 Antibody, Polyclonal antibody, could be used for WB and so on.
规格
产品名称
MTF2 Antibody
别名
MTF2抗体 | MTF2多克隆抗体
英文别名
DJ976O13.2 antibody | hPCl2 antibody | M96 antibody | metal regulatory transcription factor 2 antibody | Metal response element binding transcription factor 2 antibody | metal-response element DNA-binding protein M96 antibody | PCL2 antibody | polycomb-li
规格或纯度
见COA
生化机理
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter.