Rabbit anti Human NEIL1 Antibody, Polyclonal antibody, could be used for WB, IHC and so on.
规格
产品名称
NEIL1 Antibody
别名
核酸内切酶8样蛋白1抗体
英文别名
DNA (apurinic or apyrimidinic site) lyase Neil1 antibody | DNA glycosylase/AP lyase Neil 1 antibody | DNA glycosylase/AP lyase Neil1 antibody | DNA-(apurinic or apyrimidinic site) lyase Neil1 antibody | Endonuclease 8 like 1 antibody | Endonuclease 8-like
规格或纯度
无载体, 见COA
生化机理
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
宿主种属
兔(Rabbit)
特异性
NEIL1
种属反应性
人(Human)
免疫原
Fusion protein of human NEIL1.
阳性对照
WB: HeLa, Human cerebrum lysates. IHC: Human colorectal, tonsil cancer tissue.