Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
宿主种属
小鼠(Mouse)
特异性
OSBP1
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse),猴(Monkey)
免疫原
Recombinant full length protein of human OSBP1 produced in HEK293T cell.
阳性对照
WB: HEK293T transfected with pCMV6-ENTRY OSBP cDNA for 48 hrs; COS7, Jurkat lysates. IHC: breast adenocarcinoma, ovary adenocarcinoma tissues.