Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Post-translational: Phosphorylated by PLK. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation.
宿主种属
兔(Rabbit)
特异性
STAG1
种属反应性
人(Human)
免疫原
Fusion protein of human STAG1.
阳性对照
WB: 293T, HeLa lysates. IHC: Human tonsil, gastric cancer tissue.