Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
宿主种属
小鼠(Mouse)
特异性
SULT1A1/STP
种属反应性
人(Human)
免疫原
Recombinant full length protein of human SULT1A1/STP produced in HEK293T cell.
阳性对照
WB: HEK293, THP-1 and Hep G2 cell lysates. IHC: Human liver, pancreas tissues. IF/ICC: COS7 cells transiently transfected with pCMV6-ENTRY SULT1A1. Flow Cytometry: HEK293T cells transfected with pCMV6-ENTRY SULT1A1.
SULT1A1/STP Mouse mAb (Ab129730) - Western Blot All lanes: SULT1A1/STP Mouse mAb (Ab129730) at 1/500 dilution Samples: Lysates at 25 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/5000 dilution Predicted band size: 31 kDa Observed band size: 31 kDa Exposure time: 1.0 s
SULT1A1/STP Mouse mAb (Ab129730) - IF/ICC Immunofluorescent analysis of COS7 cells transiently transfected by pCMV6-ENTRY SULT1A1.
SULT1A1/STP Mouse mAb (Ab129730) - IHC Immunohistochemical analysis of paraffin-embedded Human liver tissue within the normal limits using SULT1A1/STP Mouse mAb (Ab129730). Heat-induced epitope retrieval by EDTA solution buffer pH 8.0 at 120°C for 3 min.
SULT1A1/STP Mouse mAb (Ab129730) - IHC Immunohistochemical analysis of paraffin-embedded Human pancreas tissue within the normal limits using SULT1A1/STP Mouse mAb (Ab129730). Heat-induced epitope retrieval by EDTA solution buffer pH 8.0 at 120°C for 3 min.
SULT1A1/STP Mouse mAb (Ab129730) - Flow Cytometry HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by SULT1A1/STP Mouse mAb (Ab129730), and then analyzed by flow cytometry.
ZJ25F0825530
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