Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity).
Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081).
This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity).
宿主种属
小鼠(Mouse)
特异性
Human CD41a
种属反应性
人(Human)
免疫原
Purified platelet membrane glycoproteins
阳性对照
Flow Cytometry: Human peripheral blood platelets
偶联
Pacific Blue
Excitation(nm)
Violet Laser(405nm)
Emission(nm)
455nm
Ex/Em(nm)
Ex:410nm;Em:455nm
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
5 μL/test
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.
防腐剂
0.05% Proclin300
储存条件
2-8°C储存,避光,禁止冷冻
运输条件
低温运输,禁止冷冻
稳定性与储存
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
图片
Recombinant CD41a Antibody (Pacific Blue) (Ab230575) - Flow Cytometry Flow cytometry analysis of CD41a expression by human peripheral blood platelets (red) compared to an isotype control (blue). Cells were stained with Recombinant CD41a Antibody (Pacific Blue) (Ab230575) at 5μL/test for 1 hour at 4°C. Blue - Mouse IgG (Pacific Blue) (Ab216764). Black - Unlabelled control, cells without incubation with primary antibody.
ZJ25F1028944
危险品化学品经营许可证（带存储）