Rabbit anti Human MCM3 Antibody, Recombinant, could be used for WB, IHC, IF/ICC and so on.
规格
产品名称
Recombinant MCM3 Antibody
规格或纯度
无载体, 重组, ExactAb™, 已验证, PBS Only, 无叠氮钠, 见COA
生化机理
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Post-translational: Phosphorylated upon DNA damage, probably by ATM or ATR.
宿主种属
兔(Rabbit)
特异性
MCM3
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human MCM3 (AA 11-24)
阳性对照
WB: Jurkat, K562, Hep G2, RAW 264.7 and C6 cell lysates. IHC: Human tonsil tissue. ICC/IF: HeLa cells.