Rabbit anti Human FKBP5 Antibody, Recombinant, could be used for WB, IF/ICC and so on.
规格
产品名称
Recombinant FKBP5 Antibody
规格或纯度
无载体, 重组, ExactAb™, 已验证, PBS Only, 无叠氮钠, 见COA
生化机理
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production.
宿主种属
兔(Rabbit)
特异性
FKBP5
种属反应性
人(Human),大鼠(Rat)
免疫原
A synthetic peptide derived from human FKBP51 (AA 400-457).