BRD4 Inhibitor-38 (Compound 25) is an orally active inhibitor of BRD4 with IC 50 values of 3.64 μM and 0.12 μM against BRD4 BD1 and BRD4 BD2 , respectively. BRD4 Inhibitor-38 also exhibits anti-inflammatory activity, with an IC 50 value of 1.98 μM for inhibiting nitric oxide (NO) production.