Blonanserin dihydrochloride is a potent and orally active 5-HT 2A and dopamine D2 receptor antagonist, with K i values of 0.812 and 0.142 nM, respectively. Blonanserin dihydrochloride is usually acts as an atypical antipsychotic agent, and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension.