BMS-604992 (EX-1314) free base is a selective, orally active small-molecule growth hormone secretagogue receptor ( GHSR ) agonist. BMS-604992 free base demonstrates high-affinity binding ( k i =2.3 nM) and potent functional activity ( EC 50 =0.4 nM). BMS-604992 free base can stimulate food intake in rodents.