计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Bupivacaine HCl 是一种更有效的cAMP生成抑制剂，IC50为2.3 μM。A Na+ channel blocker.
Information
Bupivacaine HCl Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.
In vitro
Bupivacaine solution is cytotoxic to bovine articular chondrocytes and articular cartilage in vitro after only 15 to 30 minutes exposure. Bupivacaine acts in isolated mitochondria, as uncouplers between oxygen consumption and phosphorylation of adenosine diphosphate. Bupivacaine causes a concentration-dependent mitochondrial depolarization and pyridine nucleotide oxidation in isolated mitochondria, which are matched by an increased oxygen consumption at bupivacaine concentrations of 1.5 mm or less at pH 7.4, whereas respiration is inhibited at higher concentrations. Bupivacaine causes the opening of the permeability transition pore (PTP), a cyclosporin A-sensitive inner membrane channel that plays a key role in many forms of cell death. Bupivacaine causes mitochondrial depolarization and pyridine nucleotides oxidation that are matched by increased concentrations of cytosolic free Ca(2+), release of cytochrome c, and eventually, hypercontracture in intact flexor digitorum brevis fibers. Bupivacaine inhibits GIRK channels within seconds of application, regardless of whether channels are activated through the muscarinic receptor or directly via coexpressed G protein G(beta)gamma subunits. Bupivacaine also inhibits alcohol-induced GIRK currents in the absence of functional pertussis toxin-sensitive G proteins. Bupivacaine HCl also potently inhibits cAMP production with an IC50 of 2.3 μM.
In vivo
Bupivacaine does not only induce Ca2+ release from the sarcoplasmic reticulum (SR) in rats, but also inhibits Ca2+ uptake by the SR, which is mainly regulated by SR Ca2+ adenosine triphosphatase activity.
Cell Data
cell lines：BON, QGP-1 and MIP-101 cells
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide,hydrochloride (1:1)
规格或纯度
10mM in DMSO
英文名称
Bupivacaine HCl
生化机理
盐酸布比卡因能与电压门控钠通道的细胞内部分结合，阻断钠流入神经细胞，用于治疗心律失常。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
241-917-8
分子类型
小分子
Isomeric SMILES
CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
分子量
324.89
Reaxy-Rn
4048737
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4048737&ln=
技术文档
高级数据
化学和物理性质
熔点
257°C
安全和危险性（GHS）
信号词
Danger
危险声明
H319: 引起严重眼睛刺激
H412: 对水生生物有害并具有长期持续影响
H300: 吞咽致命
预防措施声明
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P273: 避免释放到环境中。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P405: 密闭存放
P501: 将内容物/容器处理到。。。
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P330: 漱口
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P301+P316: 如果吞咽：立即寻求紧急医疗救助。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
RTECS
TK6125000
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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危险品化学品经营许可证（带存储）