BIBR 1532 BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the
In vitro

BIBR 1532 exhibits an non-competitive inhibitory effect on telomerase activity. In JVM13 leukemia cell line, BIBR 1532 shows an antiproliferative effect in a dose-dependent range with IC50 of 52 μM, and similar results are also observed in other leukemia cell lines including Nalm-1, HL-60, and Jurkat. In addition, BIBR 1532 results in a direct antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56 μM without affecting the proliferative capacity of normal hematopoietic progenitor cells. BIBR 1532 (2.5 μM) reduces colony-forming ability, and induces telomere length shortening as well as chemotherapeutic sensitization by inhibiting telomerase activity in MCF-7/WT and melphalan-resistant MCF-7/Mln^R cell lines. In T-cell prolymphocytic leukemia (T-PLL), BIBR 1532 shows selective cytotoxic effects in a dose-dependent manner and BIBR 1532-treated cells also demonstrates nuclear condensation and formation of apoptotic bodies morphologically compatible with apoptosis. A recent study shows that combination treatment of BIBR 1532 and chemotherapeutic agents carboplatin results in a potential synergy for eliminateing ovarian cancer spheroid-forming cells in ES2, SKOV3, and TOV112D cell lines.

In vivo

Cell Data

cell lines：

Concentrations：0 to 80 μM

Incubation Time：24 -72 hours

Powder Purity:≥96%

规格

英文别名

(E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid

规格或纯度

10mM in DMSO

英文名称

BIBR 1532

生化机理

BIBR 1532 是一种强效、选择性、非竞争性端粒酶抑制剂，在无细胞试验中的 IC50 为 100 nM。在大大超过端粒酶 IC50 的浓度下，对 DNA 和 RNA 聚合酶（包括 HIV 逆转录酶）均无抑制作用。BIBR 1532 可诱导癌细胞凋亡。

储存条件

-80℃储存

运输条件

特低温运输

名称和识别符

分子类型

小分子

Isomeric SMILES

C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2

分子量

331.36

Reaxy-Rn

23544604

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23544604&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

关联靶点（人）

TERT Tchem 端粒酶逆转录(Telomerase reverse transcriptase) (7 活性数据)

点击查看靶蛋白信息： TERT

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

三维染色质结构重塑与生理性衰老机制

目录：技术文章

探索主题:

三维染色质生理性衰老 A/B区室拓扑相关结构域染色质环核纤层相关结构域异染色质

Three-Dimensional Chromatin Architecture Remodeling and Mechanisms of Physiological Aging

目录：技术文章

探索主题:

three-dimensional chromatin physiological aging A/B compartments topologically associating domains chromatin loops lamina-associated domains heterochromatin

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索