计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Buflomedil HCl是一种血管扩张剂，用于治疗跛行或外周动脉疾病的症状。A neurotransmitter agent.
Information
Buflomedil HCl Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
In vitro
Buflomedil increases intracellular levels of cAMP in human keratinocytes, either secondary to phosphodiesterase inhibition (PTX) or adenyl-cyclase stimulation (BC). Buflomedil diminishes TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level. Buflomedil significantly inhibits epinephrine-induced aggregation at the micromolar level. Buflomedil results in a weak inhibition of ADP- and collagen-induced aggregation. Buflomedil inhibits granular secretion and the interaction of fibrinogen with its receptor on platelet. Buflomedil hypochloride improves the capillary perfusion in such related situations, evoking a possible effect upon neutrophils. Buflomedil decreases 100% of histamine related neutrophil adhesion (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil decreases the expression of P-selectin at the surface of endothelial cells and hypoxia induced neutrophil adhesion.
In vivo
Buflomedil (6 mg/kg) increases flap survival in nicotine treated rats. Buflomedil (3 mg/kg) significantly reduces both post-ischemic capillary perfusion failure and leukocyte adherence in venules. Buflomedil reduces the vasodilation evoked by phentolamine and potentiates its depressive effect on vasomotion frequency and amplitude in the hamster cheek pouch.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone,hydrochloride (1:1)
规格或纯度
10mM in DMSO
英文名称
Buflomedil HCl
生化机理
盐酸丁咯地尔是一种血管扩张剂，用于治疗跛行或外周动脉疾病症状；是一种非选择性α肾上腺素能受体抑制剂。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
252-611-9
分子类型
小分子
Isomeric SMILES
COC1=CC(=C(C(=C1)OC)C(=O)CCCN2CCCC2)OC.Cl
关联CAS
分子量
343.85
Reaxy-Rn
6023423
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6023423&ln=
技术文档
高级数据
化学和物理性质
熔点
193°C
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H302: 吞食有害
预防措施声明
P501: 将内容物/容器处理到。。。
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P330: 漱口
P301+P317: 如果被吞咽：请寻求医疗帮助。
RTECS
EL9900000
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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危险品化学品经营许可证（带存储）