岩白菜素

  • 10mM in DMSO
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货号 (SKU) 包装规格 是否现货 价格 数量
B408735-1ml
1ml 现货 Stock Image
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Compound libraries (12332)

基本描述

英文别名 Cuscutin | Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-
规格或纯度 10mM in DMSO
英文名称 Bergenin
生化机理 小檗苷(菟丝子苷)是三羟基苯甲酸的糖苷,也是 4-O-甲基没食子酸的 C-糖苷。
储存温度 -80℃储存
运输条件 超低温冰袋运输
产品介绍

溶于醇。无臭,味苦,遇光和受热渐渐变色。

Information

Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

产品属性

ALogP -0.849
hba_count 4
HBD Count 5
Rotatable Bond 2

关联靶点(人)

IL6 Tclin 白细胞介素-6(Interleukin-6) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

名称和识别符

Canonical SMILES COC1=C(O)C2=C(C=C1O)C(=O)OC3C(O)C(O)C(CO)OC23
分子量 328.27
Reaxy-Rn 1354737
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1354737&ln=

化学和物理性质

DMSO(mg / mL) Max Solubility 66
DMSO(mM) Max Solubility 201.05
Water(mg / mL) Max Solubility <1

安全和危险性(GHS)

Reaxy-Rn 1354737
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1354737&ln=

技术规格说明书

Concentration 9-11(mmol/L)
Infrared spectrum Conforms to Structure

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

1. Huang Dan, Sun Chaoqun, Chen Min, Bai Shuyou, Zhao Xuanna, Wang Weiming, Geng Kang, Huang Wenbo, Zhao Tingting, Wu Bin, Zhang Guilin, Wu Dong, Xu Youhua.  (2022)  Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.  Frontiers in Pharmacology,  13  [PMID:36313381] [10.3389/fphar.2022.994878]
2. Yinggui Zhu, Lili Zou, Qin Dong, Derong Jiang.  (2015)  Determination of bergenin based on the electrochemiluminescence quenching of tris(2,2′-bipyridine)-ruthenium(II).  LUMINESCENCE,  30  (8): (1269-1273).  [PMID:25808319] [10.1002/bio.2891]

参考文献

1. Huang Dan, Sun Chaoqun, Chen Min, Bai Shuyou, Zhao Xuanna, Wang Weiming, Geng Kang, Huang Wenbo, Zhao Tingting, Wu Bin, Zhang Guilin, Wu Dong, Xu Youhua.  (2022)  Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.  Frontiers in Pharmacology,  13  [PMID:36313381] [10.3389/fphar.2022.994878]
2. Yinggui Zhu, Lili Zou, Qin Dong, Derong Jiang.  (2015)  Determination of bergenin based on the electrochemiluminescence quenching of tris(2,2′-bipyridine)-ruthenium(II).  LUMINESCENCE,  30  (8): (1269-1273).  [PMID:25808319] [10.1002/bio.2891]

溶液计算器

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