| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B423892-1ml |
1ml |
现货  |
|
| 别名 | 苯扎贝特 |
|---|---|
| 英文别名 | Bezafibrate [USAN:INN:BAN:JAN] | Difaterol | MLS001148205 | Opera_ID_376 | PEM | 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID | Bezalip Retard | BM15075 | BM-15075 | KBio2_007059 | Regadrin B | BEZAFIBRATE (EP MONOGRAPH) | Bezamerck | Propionic acid, 2-(4-(2-((4 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Bezafibrate |
| 生化机理 | 贝扎贝特是一种过氧化物酶体增殖剂和降脂药，是氯贝特的衍生物。经证实，贝扎贝特可有效预防辐射和 DES 诱导的乳腺肿瘤，可能是通过降低催乳素和甘油三酯的浓度。贝扎贝特是一种 PPARα、PPARβ、PPARγ 和 LPL 的激活剂，是泛 PPAR 激动剂（对 PPARα、PPARγ 和 PPARδ 人体受体的 EC 50 值分别为 50、60 和 20 μM）。在降低体重和血糖方面比非诺贝特更有效。具有抗糖尿病和降血脂作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 过氧化物酶体增殖激活受体激动剂 |
| 产品介绍 |
Bezafibrate 是第一个临床测试的双重pan-peroxisome proliferator-activated receptors (PPAR)（过氧化物酶体增殖物激活受体）联合激动剂 Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism. |
| ALogP | 3.8 |
|---|
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 255-567-9 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid |
| INCHI | InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24) |
| InChi Key | IIBYAHWJQTYFKB-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
| Isomeric SMILES | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
| WGK Germany | 1 |
| RTECS | UE8755000 |
| 分子量 | 361.82 |
| Reaxy-Rn | 4267656 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4267656&ln= |
| 熔点 | 183-186°C |
|---|---|
| 分子量 | 361.800 g/mol |
| XLogP3 | 3.800 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 361.108 Da |
| 单同位素质量Monoisotopic Mass | 361.108 Da |
| 拓扑极表面积Topological Polar Surface Area | 75.600 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 452.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08, GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H302: 吞食有害 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。 |
| WGK Germany | 1 |
| RTECS | UE8755000 |
| Reaxy-Rn | 4267656 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4267656&ln= |
| Merck Index | 1195 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
| 1. Huimin Zhou, Zhiwei Qiu, Jin Zeng, Ruobin Dai, Zhiwei Wang. (2023) Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. JOURNAL OF MEMBRANE SCIENCE, 688 (15): (122125). [PMID:10677542] [10.1016/j.memsci.2023.122125] |
| 2. Xuecong Qian, Shilong Wang, Haijun Cheng, Ziye Jia, Da Wang, Yandong Xie, Jinhao Duan, Yu Tian, Jun Ma. (2023) Mn(II) oxidation by the UV/chlorine system under near-neutral pH conditions: The important role of ClO· and ClO2. WATER RESEARCH, 246 (28): (120673). [PMID:37844341] [10.1016/j.watres.2023.120673] |
| 3. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] [10.1021/acs.jmedchem.3c00822] |
| 4. Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2053). [PMID:36768377] [10.3390/ijms24032053] |
| 5. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. (2023) Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): (1593). [PMID:36675107] [10.3390/ijms24021593] |
| 6. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang. (2022) Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine. CHEMOSPHERE, 293 (133665). [PMID:35051510] [10.1016/j.chemosphere.2022.133665] |
| 7. Xiangyu Chen, Juanjuan Yao, Hongsen Dong, Mingjian Hong, Naiyun Gao, Zhi Zhang, Wenchao Jiang. (2021) Enhanced bezafibrate degradation and power generation via the simultaneous PMS activation in visible light photocatalytic fuel cell. WATER RESEARCH, 207 (117800). [PMID:34741902] [10.1016/j.watres.2021.117800] |
| 8. Yang Deng, Ji Ma, Xin Weng, Yuqin Wang, Maoru Li, Tingting Yang, Zhiyang Dou, Zhiqi Yin, Jing Shang. (2021) Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress. Life-Basel, 11 (5): (445). [PMID:34069176] [10.3390/life11050445] |
| 9. Yang Guo, Erzhuo Zhao, Jun Wang, Xiaoyuan Zhang, Haiou Huang, Gang Yu, Yujue Wang. (2020) Comparison of emerging contaminant abatement by conventional ozonation, catalytic ozonation, O3/H2O2 and electro-peroxone processes. JOURNAL OF HAZARDOUS MATERIALS, 389 (121829). [PMID:31836369] [10.1016/j.jhazmat.2019.121829] |
| 10. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1126-1127 (121708). [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
| 11. Ji Ma, Hongli Yin, Maoru Li, Yang Deng, Owais Ahmad, Guohong Qin, Qiangqiang He, Jiajing Li, Kai Gao, Junyi Zhu, Bing Wang, Susu Wu, Tao Wang, Jing Shang. (2019) A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs. International Journal of Biological Sciences, 15 (5): ( 973–983). [PMID:31182918] [10.7150/ijbs.30013] |
| 12. Shen Chang-shuai, Zhou Cai-rong. (2016) Investigation of the thermal decomposition kinetics of bezafibrate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 126 (2): (959-967). [10.1007/s10973-016-5565-9] |
| 13. Gao Yu-qiong, Ma Jia-xin, Rao Yan-yan, Chen Ju-xiang, Gao Nai-yun. (2024) Efficient Degradation of Bezafibrate Using the Fe(II)/Sulfite Process: Kinetics, Mechanism and Influence on DBP Formation. International Journal of Environmental Research, 18 (6): (1-16). [10.1007/s41742-024-00658-7] |
| 14. Yuqiong Gao, Kexuan Li, Xiangmei Zhong, Han Ning. (2024) Electro-Assisted Fe3+/Persulfate System for the Degradation of Bezafibrate in Water: Kinetics, Degradation Mechanism, and Toxicity. Water, 16 (5): (649). [10.3390/w16050649] |
| 15. Zekun Dong, Jie Yao, Zhihui Hu, Jiao Yang, Yan Zhang. (2024) Insight into roles of carbon anodes for removal of refractory organic contaminants in electro-peroxone system: Mechanism, performance and stability. JOURNAL OF HAZARDOUS MATERIALS, 469 (133957). [PMID:38452678] [10.1016/j.jhazmat.2024.133957] |
| 1. Huimin Zhou, Zhiwei Qiu, Jin Zeng, Ruobin Dai, Zhiwei Wang. (2023) Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. JOURNAL OF MEMBRANE SCIENCE, 688 (15): (122125). [PMID:10677542] [10.1016/j.memsci.2023.122125] |
| 2. Xuecong Qian, Shilong Wang, Haijun Cheng, Ziye Jia, Da Wang, Yandong Xie, Jinhao Duan, Yu Tian, Jun Ma. (2023) Mn(II) oxidation by the UV/chlorine system under near-neutral pH conditions: The important role of ClO· and ClO2. WATER RESEARCH, 246 (28): (120673). [PMID:37844341] [10.1016/j.watres.2023.120673] |
| 3. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] [10.1021/acs.jmedchem.3c00822] |
| 4. Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2053). [PMID:36768377] [10.3390/ijms24032053] |
| 5. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. (2023) Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): (1593). [PMID:36675107] [10.3390/ijms24021593] |
| 6. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang. (2022) Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine. CHEMOSPHERE, 293 (133665). [PMID:35051510] [10.1016/j.chemosphere.2022.133665] |
| 7. Xiangyu Chen, Juanjuan Yao, Hongsen Dong, Mingjian Hong, Naiyun Gao, Zhi Zhang, Wenchao Jiang. (2021) Enhanced bezafibrate degradation and power generation via the simultaneous PMS activation in visible light photocatalytic fuel cell. WATER RESEARCH, 207 (117800). [PMID:34741902] [10.1016/j.watres.2021.117800] |
| 8. Yang Deng, Ji Ma, Xin Weng, Yuqin Wang, Maoru Li, Tingting Yang, Zhiyang Dou, Zhiqi Yin, Jing Shang. (2021) Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress. Life-Basel, 11 (5): (445). [PMID:34069176] [10.3390/life11050445] |
| 9. Yang Guo, Erzhuo Zhao, Jun Wang, Xiaoyuan Zhang, Haiou Huang, Gang Yu, Yujue Wang. (2020) Comparison of emerging contaminant abatement by conventional ozonation, catalytic ozonation, O3/H2O2 and electro-peroxone processes. JOURNAL OF HAZARDOUS MATERIALS, 389 (121829). [PMID:31836369] [10.1016/j.jhazmat.2019.121829] |
| 10. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1126-1127 (121708). [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
| 11. Ji Ma, Hongli Yin, Maoru Li, Yang Deng, Owais Ahmad, Guohong Qin, Qiangqiang He, Jiajing Li, Kai Gao, Junyi Zhu, Bing Wang, Susu Wu, Tao Wang, Jing Shang. (2019) A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs. International Journal of Biological Sciences, 15 (5): ( 973–983). [PMID:31182918] [10.7150/ijbs.30013] |
| 12. Shen Chang-shuai, Zhou Cai-rong. (2016) Investigation of the thermal decomposition kinetics of bezafibrate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 126 (2): (959-967). [10.1007/s10973-016-5565-9] |
| 13. Gao Yu-qiong, Ma Jia-xin, Rao Yan-yan, Chen Ju-xiang, Gao Nai-yun. (2024) Efficient Degradation of Bezafibrate Using the Fe(II)/Sulfite Process: Kinetics, Mechanism and Influence on DBP Formation. International Journal of Environmental Research, 18 (6): (1-16). [10.1007/s41742-024-00658-7] |
| 14. Yuqiong Gao, Kexuan Li, Xiangmei Zhong, Han Ning. (2024) Electro-Assisted Fe3+/Persulfate System for the Degradation of Bezafibrate in Water: Kinetics, Degradation Mechanism, and Toxicity. Water, 16 (5): (649). [10.3390/w16050649] |
| 15. Zekun Dong, Jie Yao, Zhihui Hu, Jiao Yang, Yan Zhang. (2024) Insight into roles of carbon anodes for removal of refractory organic contaminants in electro-peroxone system: Mechanism, performance and stability. JOURNAL OF HAZARDOUS MATERIALS, 469 (133957). [PMID:38452678] [10.1016/j.jhazmat.2024.133957] |
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