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浴铜灵二磺酸二钠盐水合物

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
B486593-250mg
250mg 现货 Stock Image
B486593-1g
1g 现货 Stock Image

基本描述

英文别名 1257642-74-2|Bathocuproinedisulfonic acid disodium salt hydrate|Sodium 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline-3,8-disulfonate hydrate|disodium;2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline-3,8-disulfonate;hydrate|Disodium bathocuproine disulfonate|
英文名称 Bathocuproinedisulfonic acid disodium salt hydrate
产品介绍

浴铜灵二磺酸二钠盐 (BCDS) 是一种稳定的 Cu+螯合剂,BCDS-Cu+抑制 HIV-1 野生型蛋白酶以及缺乏半胱氨酸的突变型 HIV-1 蛋白酶 。是一种细胞外铜螯合剂 。


应用

在电子自旋共振自旋捕集技术中,以浴铜灵二磺酸二钠水合盐为螯合剂,研究急性甲酸钠中毒大鼠自由基的产生 。将其作为测定 Cu 和 Cu 蛋白复合物的试剂。

Bathocuproine disulfonic acid (BCDS) is a stable Cu+chelator and BCDS-Cu+inhibits the HIV-1 wild type protease as well as a mutant HIV-1 protease lacking cysteine. It is an extracellular copper chelator.Bathocuproinedisulfonic acid disodium salt hydrate was used as chelator in electron spin resonance spin trapping technique to study free radical generation in rats with acute sodium formate poisoning. It was used as reagent for determination of Cu and Cu-protein complexes.

名称和标识符

PubChem SID 488202189
PubChem SID url https://pubchem.ncbi.nlm.nih.gov/substance/488202189
IUPAC Name disodium;2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline-3,8-disulfonate;hydrate
INCHI InChI=1S/C26H20N2O6S2.2Na.H2O/c1-15-25(35(29,30)31)21(17-9-5-3-6-10-17)19-13-14-20-22(18-11-7-4-8-12-18)26(36(32,33)34)16(2)28-24(20)23(19)27-15;;;/h3-14H,1-2H3,(H,29,30,31)(H,32,33,34);;;1H2/q;2*+1;/p-2
InChi Key ZAGWMJUGRCMNGX-UHFFFAOYSA-L
Canonical SMILES CC1=C(C(=C2C=CC3=C(C(=C(N=C3C2=N1)C)S(=O)(=O)[O-])C4=CC=CC=C4)C5=CC=CC=C5)S(=O)(=O)[O-].O.[Na+].[Na+]
Isomeric SMILES CC1=C(C(=C2C=CC3=C(C(=C(N=C3C2=N1)C)S(=O)(=O)[O-])C4=CC=CC=C4)C5=CC=CC=C5)S(=O)(=O)[O-].O.[Na+].[Na+]
WGK Germany 3
PubChem CID 71306850
分子量 564.54 (anhydrous basis)

安全和危险性(GHS)

信号词 Warning
危险声明 H413: May cause long lasting harmful effects to aquatic life
H302: Harmful if swallowed
预防措施声明 P273,P501,P264,P270,P301+P312+P330
WGK Germany 3
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR NONHforallmodesoftransport

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参考文献

1. D A Davis,A A Branca,A J Pallenberg,T M Marschner,L M Patt,L G Chatlynne,R W Humphrey,R Yarchoan,R L Levine.  (1995-09-10)  Inhibition of the human immunodeficiency virus-1 protease and human immunodeficiency virus-1 replication by bathocuproine disulfonic acid Cu1+..  Archives of biochemistry and biophysics,  322  ((1)):  (127-134).  [PMID:7574666]
2. M Matsushita,T Irino,T Komoda,Y Sakagishi.  (1993-07-16)  Determination of proteins by a reverse biuret method combined with the copper-bathocuproine chelate reaction..  Clinica chimica acta; international journal of clinical chemistry,  216  ((1-2)):  (103-111).  [PMID:8222260]
3. Dieter Egli,Anand Selvaraj,Hasmik Yepiskoposyan,Bo Zhang,Ernst Hafen,Oleg Georgiev,Walter Schaffner.  (2002-12-31)  Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis..  The EMBO journal,  22  ((1)):  (100-108).  [PMID:12505988]
4. Eric Bakker.  (2010-08-10)  Generalized Selectivity Description for Polymeric Ion-Selective Electrodes Based on the Phase Boundary Potential Model..  Journal of electroanalytical chemistry (Lausanne, Switzerland),  639  ((1-2)):  (1-7).  [PMID:20694153]
5. Qiong Hu,Baojing Zhou,Feng Li,Jinming Kong,Xueji Zhang.  (2016-09-13)  Turn-On Colorimetric Platform for Dual Activity Detection of Acid and Alkaline Phosphatase in Human Whole Blood..  Chemistry, an Asian journal,  11  ((21)):  (3040-3045).  [PMID:27615725]
6. Monirul Islam,Massimo E Maffei,Gianpiero Vigani.  (2020-05-07)  The Geomagnetic Field Is a Contributing Factor for an Efficient Iron Uptake in Arabidopsis thaliana..  Frontiers in plant science,  11  ():  (325-325).  [PMID:32373135]