计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
BAY-747 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase ( sGC ). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model
In Vitro
BAY-747 (100 nM) enhances AMPA receptor dynamics in an ex vivo acquisition-like cLTP model, in combination with WS. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: ex vivo acquisition-like cLTP model Concentration: 100 nM Incubation Time: Result: Increased the phosphorylation levels of S845 on GluA1.
In Vivo
BAY-747 shows a brain to plasma ratio of 0.6 ± 2.0 at the investigated time frame, reflecting a relatively high brain penetration of 60% . BAY-747 (0.03-1.0 mg/kg,2 mL/kg ; po; 30 min before T1 in a 24 h interval OLT) enhance long-term memory acquisition processes in rat object location task (OLT) model, and also attenuates L-NAME induced short-term memory impairments. BAY-747 does not affect GluA1-containing AMPAR dynamics in the hippocampus . BAY-747 (0.003-0.3 mg/kg; po; single dose) decreases blood pressure in rats, and also (3 mg/kg; po; once daily for 35 days) increases body weight of rats in l-NAME-Treated Renin Transgenic model. BAY-747 (150 mg/kg of food; po; 16 weeks) improves grip strength and running speed in male mdx/mTRG2 mice, suggesting improved skeletal muscle function. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat object location task (OLT) model Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration: PO; 30 min before T1 in a 24 h interval OLT Result: Resulted significantly higher long-term memory performance at 0.03, 0.1, 0.3 and 1.0 mg/kg dose, 30 min before T1. Attenuated L-NAME induced short-term memory impairments at 0.3 mg/kg and 1 mg/kg. Did not enhance GluA1 trafficking at 1 mg/kg 24 h after treatment. Animal Model: Anesthetized, conscious spontaneously hypertensive and conscious normotensive ratsDosage: 0 mg/kg, 0.003 mg/kg, 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, and 0.3 mg/kg Administration: IV; single dose Result: Produced a dose-dependent and long-lasting decrease in blood pressure in rats. Animal Model: l-NAME-Treated Renin Transgenic RatsDosage: 0.3 mg/kg, 3 mg/kg Administration: PO; once daily for 35 days; l-NAME treatment: 30 mg/kg, po, for 6 days Result: Resulted a significant weight gain among rats. Led to a dose-dependent increase of plasma cGMP. Decreased blood pressure only at 3 mg/kg.
IC50& Target:Soluble guanylate cyclase (sGC)
规格
英文名称
BAY-747
生化机理
BAY-747（BAY 1165747）是一种具有口服活性的可溶性鸟苷酸环化酶（sGC）脑促进剂。BAY-747 可逆转 L-NAME 诱导的记忆损伤，并增强大鼠在物体定位任务（OLT）中的认知能力。BAY-747 还能降低大鼠的血压。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激活剂
名称和识别符
分子类型
小分子
分子量
416.46
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
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溶液计算器
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