计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase ( PKA ) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase ( PDE ) inhibitor.
In Vivo
Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats . ?\nBucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine. ?\nBucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin. ?\nBucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
规格
别名
布拉地辛钙
英文名称
Bucladesine calcium
生化机理
Bucladesine钙盐（二丁酰基-cAMP钙盐；DC2797钙盐）是一种细胞渗透性环磷酸腺苷（cAMP）类似物，可通过增加细胞内的 cAMP 水平选择性地激活 cAMP 依赖性蛋白激酶（PKA）。布卡拉丁钙盐
储存条件
2-8°C储存,干燥
运输条件
低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
INCHI
1S/2C18H24N5O8P.Ca/c2*1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h2*8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/t2*10-,14-,15-,18-;/m11./s1
InChi Key
DRYMTGFYEAYJQR-NGVPHMJWSA-N
Smiles
CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)O)OC(=O)CCC.CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)O)OC(=O)CCC.[Ca]
PubChem CID
分子量
488.42
技术文档
高级数据
三维结构
交互式化学结构模型
化学和物理性质
溶解性
H2O : 100 mg/mL (204.74 mM; Need ultrasonic) DMSO : ≥ 100 mg/mL (204.74 mM)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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