BRD0209 is a potent, selective and dual inhibitor of GSK3α/β inhibitor (GSK3α IC 50 = 19 nM; GSK3β IC 50 = 5 nM). BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics ( K i = 4.2 nM, respectively). BRD0209 is a tricyclic pyrazolotetrahydroquinolinone compound. BRD0209 has the potential for the research of mood disorder diseases.
Form:Solid
规格
英文名称
BRD0209
生化机理
BRD0209 是一种强效、选择性的 GSK3α/β 双抑制剂(GSK3α IC 50 = 19 nM;GSK3β IC 50 = 5 nM)。BRD0209 还是一种可逆的 ATP 竞争性抑制剂,具有快速关闭动力学(K i = 4.2 nM)。BRD0209 是一种三环吡唑类抑制剂。