计算溶液所需的质量、体积或浓度。
概述
BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC 50 s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation
In Vitro
BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC 50 s of 16, 82, 63 and 35 nM, respectively. BAY-390 inhibits mTRPA1, gpTRPA1, dogTRPA1 and monkeyTRPA1 with IC 50 s of 73, 68, 81 and 19 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BAY-390 (30 and 90 mg/kg; p.o.; BID for 10 days) effects the neuropathic pain in vivo . BAY-390 reduces visceral pain in rat cyclophosphamide induced cystitis models . BAY-390 shows efficacy in inflammatory pain and neurogenic inflammation models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nrodent animals with neuropathic pain Dosage: 30 and 90 mg/kg Administration: Oral gavage; 30 and 90 mg/kg; twice daily for 10 days Result: Effectively reduced the neuropathic pain in rodent neuropathic pain model.
Form:Oil
IC50& Target:IC50: 16 nM (hTRPA1 FLIPR), 82 nM (hTRPA1 Ephys), 63 nM (rTRPA1 FLIPR), 35 nM (rDRG Ephys), 73 nM (mTRPA1), 68 nM (gpTRPA1), 81 nM (dogTRPA1)m, 19 nM (monkeyTRPA1)
规格
英文名称
BAY-390
生化机理
BAY-390 是一种具有选择性、跨物种活性和脑穿透性的 TRPA1 抑制剂。BAY-390 可抑制 hTRPA1 FLIPR、hTRPA1 Ephys、rTRPA1 FLIPR 和 rDRG Ephys，其 IC 50 s 分别为 16、82、63 和 35 nM。BAY-390可用于研究infla和infla-infla-infla-infla-infla-infla-infla。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
分子量
277.26
高级数据
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溶液计算器
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