计算溶液所需的质量、体积或浓度。
,适用于对基线干扰要求严格的色谱和分析工作流程。
充氩,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
BF 227 is a candidate for an amyloid imaging probe for PET, with a K i of 4.3 nM for Aβ1-42 fibrils .
In Vitro
BF-227 has a high binding affinity for Aβ1-42 fibrils. The K i value for Aβ1-42 fibrils in competitive binding assay using [ 125 I]BF-180 is 4.3±1.3 nM in BF-227 (K d value of [ 125 I]BF-180: 10.8±1.5 nM). [ 11 C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:Ki: 4.3 nM (Aβ1-42)