计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat
In Vitro
BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rats induced by ligation of left L5 and L6 spinal nerves . Dosage: 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. Administration: Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12. Result: 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.
IC50& Target:GDNF receptor RET
规格
规格或纯度
10mM in DMSO
英文名称
BT-13
生化机理
BT-13 是一种强效的选择性神经胶质细胞系源性神经营养因子（GDNF）受体 RET 激动剂，独立于神经胶质细胞系源性神经营养因子，可促进体外感觉神经元的神经元生长，并减轻大鼠的实验性神经病变。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
名称和识别符
分子类型
小分子
Isomeric SMILES
CCN(CC)S(=O)(=O)C1=CC(=C(C=C1)OC)N2CCN(CC2)C(=O)C3=C(C=C(C=C3)F)C(F)(F)F
PubChem CID
分子量
517.54
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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