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BPR1J-097 Hydrochloride is a novel and potent FLT3 inhibitor with an IC 50 of 11 nM.
IC50& Target:IC50: 11 nM (FLT3)
In Vitro:BPR1J-097 Hydrochloride is a novel and potent FLT3 inhibitor with an IC 50 of 11nM. Phosphorylation of all FLT3-WT, FLT3-IDT, and FLT3-D835Y are inhibited by BPR1J-097 Hydrochloride at a concentration as low as 10 nM. BPR1J-097 Hydrochloride suppresses th
In Vivo:After i.v. administration of mice with BPR1J-097 Hydrochloride at two cycles of 10 or 25mg/kg, a clear dose-dependent anti-tumour effect is observed. Tumours in mice treated with BPR1J-097 Hydrochloride (25mg/kg per day) stop growing. BPR1J-097 Hydrochl
Biological Activity:BPR1J-097 Hydrochloride is a novel and potent FLT3 inhibitor with an IC 50 of 11u2009nM.