β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt -target genes level ( Fgf20 and Sall4 ). β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability.