CDK7-IN-20 is a potent, selective and irreversible CDK7 ( CDK ) inhibitor with an IC 50 value of 4 nM. CDK7-IN-20 displays >206-fold selectivity for CDK7 over CDK1 , CDK2 , CDK3 , CDK5 , CDK6 , CDK9 and CDK12. CDK7-IN-20 has the potential for autosomal dominant polycystic kidney disease (ADPKD) research.