CBPD-268 is a potent and orally active CBP/p300 PROTAC degrader with an DC 50 value of ≤ 0.03 nM. CBPD-268 induces CBP/p300 degradation and inhibits cell growth. CBPD-268 shows antitumor activity. CBPD-268 has the potential for the research of AR-positive prostate cancer (Structure Note: Red, Androgen receptor degrader ; Blue, CBP/p300 ligand ; Black, Linker).