CB1/2 agonist 4 is a full CB1 agonist and CB2 partial agonist with EC 50 values of 15.09 nM and 1.16 nM, respectively. CB1/2 agonist 4 also has hCB1 and hCB2 receptor affinities with K i values of 1.1 nM and 4.2 nM, respectively. CB1/2 agonist 4 has a significant antinociceptive activity, and also can activate cannabinoid and TRPV1 receptor with values of IC 50 and EC 50 is 0.8 μM and 0.12 μM, respectively.