COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX ( IC 50 =49 nM for COX-2 , 10.4 μM for COX-1 ) and 5-LOX ( IC 50 =2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss K i values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect.