Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels ( Ca v α2δ-1) and the norepinephrine transporter ( NET ). Cavα2δ1&NET-IN-1 inhibits Ca v α2δ-1 with a K i of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a K i of 383 nM and IC 50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain.