Cavα2δ1&NET-IN-3 (example 216) is an inhibitor of the subunit α2δ of voltage-gated calcium channels (VGCC) and noradrenaline transporter (NET). Cavα2δ1&NET-IN-3 has K i s of 100-500 nM for human α2δ-1 subunit of Ca v 2.2 calcium channel and NET, respectively.