Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels ( Ca v α2δ-1) and the norepinephrine transporter ( NET ). Cavα2δ1&NET-IN-2 inhibits Ca v α2δ-1 with a K i of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a K i of 59 nM and IC 50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain.