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,适用于对基线干扰要求严格的色谱和分析工作流程。
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COR628 is a positive allosteric modulator of GABA(B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen. The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration.