COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase ( COMT ) inhibitor with IC 50 s of 0.37 μM, 95.58 μM and 58.82 μM for COMT , MAO-A and MAO-B , respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP -induced Parkinson's disease (PD) symptoms in mice.