CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC 50 value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor ( IR ), vascular endothelial growth factor receptor 2 ( VEGFR2 ), angiopoietin-1 receptor ( TIE2 ) and dual leucine zipper kinase ( DLK ). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma.