金属和金属氧化物纳米粒子因其在治疗耐药菌感染方面的良好效果，受到了极大的关注。在抑菌过程中，活性氧（ROS）引起的氧化应激是该类抑菌剂发挥治疗作用的重要机制。然而，在缺氧环境下，ROS难以形成，影响了大多数金属及其氧化物的抗菌活性。过氧化钙（CaO₂）作为固态的过氧化氢源可在无氧条件下有效生成过氧化氢（H₂O₂），为缓解乏氧环境，提高内源性过氧化氢，提高抗肿瘤和细菌感染的临床治疗效果提供了策略。
阿拉丁提供过氧化钙纳米颗粒，尺寸约为 60-70 nm，具有良好的溶解性，在水环境下会分解产生过氧化氢与氧气，可用于可控释放H₂O₂，被广泛用于缓解乏氧环境，与纳米酶相结合进行肿瘤治疗、细菌感染治疗、生物传感和微环境相应释放等生物医学领域。
货号
| C1520779
|
产品名称
| 过氧化钙纳米颗粒
|
表面修饰
| PVP |
| 浓度 | 5 mg/mL |
平均粒径
| 60-70 nm |
水动力尺寸
| 200 nm |
Zeta
| 5.29 mV
|
分散溶剂
| 无水乙醇 |
产品参数
1. TEM表征
图1. CaO₂ 纳米颗粒的 TEM 图像，为均匀分散的纳米颗粒状，尺寸约为 60-70 nm
2. 水动力尺寸表征
图2. CaO₂纳米颗粒的 DLS 图（左边：Intensity，右边：Number）
PVP 修饰的 CaO₂ 纳米粒子的水动力尺寸比 TEM 尺寸偏大。Z-Average：214 nm，Polydispersity Index (PI)：0.04204，Intensity (nm)：226.2 nm，Number (nm)：190.5 nm（在乙醇中测试）
3. Zeta 电位表征
图3. CaO₂ 纳米颗粒的 Zeta 电位图，PVP 修饰的 CaO₂ 纳米粒子的 Zeta 电位为 5.29 mV
注意事项
CaO₂纳米颗粒在水中会发生分解，空气中 CO₂ 会与 CaO₂ 反应生产CaCO₃。
Metal and metal oxide nanoparticles have attracted great attention due to their good efficacy in treating drug-resistant bacterial infections. In the antibacterial process, oxidative stress caused by reactive oxygen species (ROS) is an important mechanism by which these antibacterial agents exert their therapeutic effects. However, in hypoxic environments, ROS are difficult to generate, which affects the antibacterial activity of most metals and their oxides. Calcium peroxide (CaO₂), as a solid hydrogen peroxide source, can effectively generate hydrogen peroxide (H₂O₂) under anoxic conditions, providing a strategy to alleviate hypoxic environments, increase endogenous H₂O₂, and improve the clinical therapeutic efficacy against tumors and bacterial infections.
Aladdin provides Calcium Peroxide Nanoparticles, approximately 60‑70 nm in size, with good solubility. In an aqueous environment, they decompose to produce hydrogen peroxide and oxygen. They can be used for controlled release of H₂O₂ and are widely applied in biomedical fields such as alleviating hypoxic environments, combination with nanozymes for tumor therapy, bacterial infection therapy, biosensing, and microenvironment‑responsive release.
| Cat. No. | C1520779 |
|---|
| Product Name | Calcium Peroxide Nanoparticles | | Surface Modification | PVP | | Concentration | 5 mg/mL | | Average Particle Size | 60‑70 nm | | Hydrodynamic Size | 200 nm | | Zeta Potential | 5.29 mV | | Dispersion Solvent | Anhydrous ethanol |
|
Product Parameters
1. TEM Characterization
Figure 1. TEM image of CaO₂ nanoparticles showing uniformly dispersed nanoparticles with a size of approximately 60‑70 nm.
2. Hydrodynamic Size Characterization
Figure 2. DLS plot of CaO₂ nanoparticles (Left: Intensity; Right: Number). The hydrodynamic size of PVP‑modified CaO₂ nanoparticles is larger than the TEM size.
Z‑Average: 214 nm, Polydispersity Index (PI): 0.04204, Intensity (nm): 226.2 nm, Number (nm): 190.5 nm (measured in ethanol).
3. Zeta Potential Characterization
Figure 3. Zeta potential plot of CaO₂ nanoparticles. The Zeta potential of PVP‑modified CaO₂ nanoparticles is 5.29 mV.
Notes
ZJ26F0738116
危险品化学品经营许可证（带存储）